Confirming or Ruling out Hereditary Elliptocytosis / Reply

The 4.1.(-) hereditary elliptocytosis.

Erythrocyte deformability and hereditary elliptocytosis.

Hereditary elliptocytosis (HE) is a hereditary membranopathy that comprises a heterogeneous group of diseases, which share irreversible erythrocyte elongation with a prolonged longitudinal diameter in relation to the cross-section (elliptocytes and ovalocytes), which acts as a morphological sign to guide diagnosis. It is characterised by certain molecular alterations to cytoskeleton proteins, s...

Abnormal spectrin in hereditary elliptocytosis.

An abnormal alpha subunit of erythrocyte spectrin has been described in hereditary pyropoikilocytosis (HPP), a rare hemolytic anemia characterized by erythrocyte budding and fragmentation. In HPP spectrin, the N terminal domain of the alpha subunit (alpha I T80) shows increased susceptibility to tryptic digestion, resulting in cleavage to a 50,000-d peptide, presumably due to a change in primar...

Ruling out and ruling in neural codes.

The subject of neural coding has generated much debate. A key issue is whether the nervous system uses coarse or fine coding. Each has different strengths and weaknesses and, therefore, different implications for how the brain computes. For example, the strength of coarse coding is that it is robust to fluctuations in spike arrival times; downstream neurons do not have to keep track of the deta...

Ruling Out Bacillus anthracis

Optimization of methods for ruling out Bacillus anthracis leads to increased yields, faster turnaround times, and a lighter workload. We used 72 environmental non-B. anthracis bacilli to validate methods for ruling out B. anthracis. Most effective were the use of horse blood agar, motility testing after isolates had a 2-h incubation in trypticase soy broth, and screening isolates with a B. anth...